BRP Outcomes

Publications

2004
Jang, J.H., Houchin T.L. and Shea L.D. , “Gene Delivery from Polymer Scaffolds for Tissue Engineering,” Exp. Rev. Med. Dev. , 2004, 1(1), 127-138.

2005
Behanna, H.A. and Stupp, S.I. , “ Synthesis of Stilbene Carboxylic Acids as Scaffolds for Calcium Sensors ,” Chem. Comm. 2005, 4845-4847.

Bull, S.R., Guler, M.O., Bras, R.E., Venkatasubramanian, P.N., Stupp, S.I. and Meade, T.J., “Magnetic Resonance Imaging of Self-Assembled Biomaterial Scaffolds,” Bioconjugate Chem. 2005, 16, 1343-1348.

Guler, M.O., Soukasene, S., Hulvat, J.F. and Stupp, S.I ., “Presentation and Recognition of Biotin on Nanofibers Formed by Branched Peptide Amphiphiles,” Nano Lett. 2005, 5, 249-252.

Guler, M.O., Claussen, R.C. and Stupp, S.I ., “Encapsulation of Pyrene within Self-Assembled Peptide Amphiphile Nanofibers,” J. Mater. Chem. 2005, 15, 4507-4512.

Harrington, D.A., Behanna, H.A., Tew, G.N., Claussen, R.C. and Stupp, S.I ., “Supramolecular Fluorophores for Biological Studies: Phenylene Vinylene – Amino Acid Amphiphiles,” Chem. Biol. 2005, 12, 1085-1091.

Jang, J., Rives, C. and Shea, L.D. , “ Plasmid Delivery in Vivo from Porous Tissue-Engineering Scaffolds: Transgene Expression and Cellular Transfection,” Mol. Ther. , 2005, 12(3), 475-483.

Yang, Y., De Laporte L., Rives, C., Jang, J.H., Shull, K. and Shea, L.D. , “Neurotrophin Releasing Single and Multiple Lumen Nerve Conduits,” J. Cont. Rel . 2005, 104(3), 433-46.

2006
Blomeier, H., Zhang, X., Rives, C., Hughes, E., Baker, M., Brissova, M., Powers, A.C., Kaufman, D.B., Shea, L.D. and Lowe, W.L. , “Polymer Scaffolds as Synthetic Microenvironments for Extrahepatic Islet Transplantation,” Transplantation 2006, 82(4), 452-9.

Chen, X., Zhang, X., Larson, C.S., Baker, M.S., and Kaufman, D.B. , “In vivo Bioluminescence Imaging of Transplanted Islets and Early Detection of Graft Rejection,” Transplantation 2006, 81(10), 1421-7.

De Laporte, L., Cruz-Rea, J. and Shea, L.D. , “Modular Non-viral Vectors for Gene Delivery”, Biomaterials 2006, 27, 947-954.

Harrington, D.A., Cheng, E.Y., Guler, M.O., Lee, L.K., Donovan, J.L., Claussen, R.C. and Stupp, S.I. , “Branched Peptide Amphiphiles as Self –Assembling Coatings for Tissue Engineering Scaffolds,” Journal of Biomedical Materials Research – Part A 2006, 78A(1), 157-67.

Jang, J.H. and Shea, L.D. , “Intramuscular Delivery of DNA Releasing Microspheres: Microsphere Properties and Transgene Expression,” J Control Release, 2006 112(1), 120-8 .

Jang, J.H., Houchin, T., Bengali, Z. and Shea. L.D. , “ Surface Adsorption of DNA to Tissue Engineering Scaffolds for Efficient Gene Delivery, ” J Biomed Mater Res A ., 2006 77(1), 50-8 .

Rajangam, K., Behanna, H.A., Hui, M.J., Han, X, Hulvat, J.F., Lomasney, J.W. and Stupp, S.I. , “Heparin Binding Nanostructures to Promote Growth of Blood Vessels,” Nano Letters 2006, 6(9), 2086-2090.

Salvay, D. and Shea, L.D. , “Inductive Tissue Engineering by Protein and DNA Releasing Scaffolds,” Mol Biosyst , 2006, 2(1), 36-48.

Stendahl, J.C., Rao, M.S., Guler, M.O. and Stupp, S.I. , “Intermolecular Forces in the Self-Assembly of Peptide Amphiphile Nanofibers,” Adv. Funct. Mater. 2006, 16(4), 499-508.

Whittlesey, K.J. and Shea, L.D. , “Neurotrophic Factor Expression by Degradable Scaffold-mediated Lipofection,” Biomaterials 2006, 27(11), 2477-86.

2007
Burke , S.A. , Ritter-Jones, M., Lee, B.P. and Messersmith, P.B. , “Temperature Triggered Gelation and Tissue Adhesion of Protein Mimetic Hydrogels,” Biomed. Mater. 2007, 2, 203-210.

Chen, X., Zhang, X., Larson, C., Chen, F., Kissler, H. and Kaufman, D.B. , “The Epididymal Fat Pad as a Transplant Site for Minimal Islet Mass,” Transplantation 2007, 84(1), 122-5.

De Laporte, L. and Shea L.D. , “Matrices and Scaffolds for DNA Delivery in Tissue Engineering,” Adv. Drug Del. Reviews, 2007, 59(4-5), 292-307.

Guler, M.O. and Stupp, S.I. , “A Self-Assembled Nanofiber Catalyst for Ester Hydrolysis,” J. Am. Chem. Soc 2007, 129(40), 12082-12083.

Houchin, T.L., Swift, L., Jang, J.H., and Shea, L.D. , “ Patterned PLG Substrates for Localized DNA Delivery and Directed Neurite Extension, “ Biomat. 2007, 28(16), 2603-11.

Hu, B.H., Ritter-Jones, M., and Messersmith, P.B. , “An Improved Method for Screening and MALDI-TOF MS Sequencing of Encoded Combinatorial Libraries,” Analytical Chemistry 2007, 79, 7275-85.

Karfeld, L.S., Bull, S.R., Davis , N.E., Meade, T.J. and Barron, A.E. , "Use of a Genetically Engineered Protein for the Design of a Multivalent MRI Contrast Agent," Bioconjugate Chemistry 2007, 18, 1697-1700.

Lee, H. and Messersmith, P.B. , “Bio-Inspired Nano-Materials for a New Generation of Medicine,” Nanotechnology in Biology and Medicine 2007, 3,1-20.

Ritter Jones, M. and Messersmith, P.B. , “Facile Coupling of Synthetic Peptides and Peptide-Polymer Conjugates to Tissue via Transglutaminase Enzyme,” Biomaterials 2007, 28, 5215-24.

Storrie, H., Guler, M.O., Abu-Amara, S.N., Volberg, T., Rao, M., Geiger, B. and Stupp S.I. , “Supramolecular Crafting of Cell Adhesion,” Biomaterials 2007, 28(31), 4608-4618.

2008
Aronovitz, A., Josefson, J., Fisher, A., Newman, M.V., Hughes, E., Chen, F., Moons D.S, Kiyokawa, H., Lowe, Jr., W.L. “Rapamycin Inhibits Growth Factor-Induced Cell Cycle Progression in Pancreatic Beta Cells ,” J. Investig. Med 2008, 56, 985-996 . NIHMS in process.

Capito, R., Azevedo, H., Velichko, Y., Mata, A., and Stupp, S.I. , “Self-Assembly of Large and Small Molecules Into Hierarchically Ordered Sacs and Membranes,” Science 2008 319(5871), 1812-1816.

Chen, X., Zhang, X., Larson, C., Xia, G., and Kaufman, D.B. , “Prolonging Islet Allograft Survival using In Vivo Bioluminescence Imaging to Guide Timing of Antilymphocyte Serum Treatment of Rejection,” Transplantation 2008, 85(9), 1246-52. NIHMS76684

Kapadia M.R., Chow L.W., Tsihlis N.D., Ahanchi S.S., Eng J.W., Murar J., Martinez J., Popowich D.A., Jiang Q., Hrabie J.A., Saavedra J.E., Keefer L.K., Hulvat J.F., Stupp S.I. , and Kibbe M.R., “Nitric Oxide and Nanotechnology: A Novel Approach to Inhibit Neointimal Hyperplasia,” J Vasc Surg 2008, 47(1), 173-182.

Liu, Z., Hu, B.H. and Messersmith, P.B. , “Convenient Synthesis of Acetonide Protected 3,4-Dihydroxyphenylalanine (DOPA) for Fmoc Solid-Phase Peptide Synthesis,” Tetrahedron Letters 2008, 49(38), 5519-5521.

Luo, X., Pothoven, K.L., McCarty, D., DeGutes, M., Martin, A., Getts, D.R., Xia, G., He, J., Zhang, X., Kaufman, D.B. and Miller, S.D., “ECDI-fixed Allogeneic Splenocytes Induce Donor Specific Tolerance for Long-Term Survival of Islet Transplants via Two Distinct Mechanisms,” PNAS, 2008, 105, 14527-32.

Messersmith, P.B. , “Multitasking in Tissues and Materials”, Science 2008, 319, 1767-8.

Niece, K.L., Czeisler, C., Sahni, V., Tysseling-Mattiace, V.M., Pashuck, E.T., Kessler, J.A. and Stupp, S.I. , “Modification of Gelation Kinetics in Bioactive Peptide Amphiphiles,” Biomaterials 2008, 29(34), 4501-4509. PMCID: PMC2584653

Palmer, L.C. and Stupp, S.I. , “Molecular Self-Assembly into One-Dimensional Nanostructures,” Accounts of Chemical Research 2008, 41(12), 1674-1684. PMCID: PMC2645948

Rajangam, K., Arnold , M., Rocco, M., and Stupp, S.l. , “Peptide Amphiphile Nanostructure-Heparin Interactions and their Relationship to Bioactivity,” Biomaterials 2008, 29(23), 3298-3305. PMCID: PMC2526463

Rea, J.C., Barron, A.E., and Shea, L.D. “Peptide-Mediated Lipofection is Governed by Lipoplex Physical Properties and the Density of Surface-displayed Amines,” J Pharm Sci . 2008, 97(11), 4794-806. NIHMS76358

Salvay, D.M., Rives, C.B., Zhang, X., Chen, F., Kaufman, D.B., Lowe, W.L., and Shea, L.D. , “ Extracellular Matrix Proteins Adsorbed to PLG Microporous Scaffolds Promote the Reversal of Diabetes Following Extrahepatic Islet Transplantation,” Transplantation 2008, 85(10), 1456-64. NIHMS 65858

Sargeant, T.D., Rao, M.S., Koh, C.Y., and Stupp, S.I. , “Covalent Functionalization of NiTi Surfaces with Bioactive Peptide Amphiphile Nanofibers,” Biomaterials 2008, 29(8), 1085-1098.

Statz, A.R., Park, J.P., Chongsiriwatana, N.P., Barron, A.E. and Messersmith, P.B. , “Surface-Immobilized Antimicrobial Peptoids,” Biofouling 2008, 24(6), 439-448.

Stendahl, J.C., Wang, L.J., Chow, L.W., Kaufman, D.B. and Stupp, S.I. , “Growth Factor Delivery from Self-Assembling Nanofibers to Facilitate Islet Transplantation,” Transplantation 2008, 86(3), 478-481. PMCID: PMC2585821

Tsonchev, S., Niece, K.L., Schatz, G.C., Ratner, M.A. and Stupp, S.I. , “Phase Diagram for Assembly of Biologically-Active Peptide Amphiphiles,” J. Phys. Chem. B 2008, 112(2), 441-447.

Tysseling-Mattiace, V.M., Sahni, V., Niece, K.L., Birch, D., Czeisler, C., Fehlings, M.G., Stupp, S.I. and Kessler, J.A. , “Self-Assembling Nanofibers Inhibit Glial Scar Formation and Promote Axon Elongation after Spinal Cord Injury,” J. Neurosci . 2008, 28(14), 3814-3823.

Velichko, Y.S., Stupp, S.I. and de la Cruz, M.O., “Molecular Simulation Study of Peptide Amphiphile Self-Assembly,” J. Phys. Chem. B 2008, 112(8), 2326-2334.

2009
Cui, H., Muroaka,T., Cheetham, A. and Stupp, S.I. , “Self-Assembly of Giant Peptide Nanobelts,” Nanoletters, 2009 9(3), 945-951. PMC Journal in process.

Davis , N.E., Karfeld-Sulzer, L.S., Ding, S. and Barron, A.E. , “Synthesis and Characterization of a New Class of Cationic Protein Polymers for Multivalent Display and Biomaterial Applications,” Biomacromolecules, 2009, 10, 1125-1134.

De Laporte, L., Yang, Y., Zelivyanskaya, M., Cummings, B., Anderson, A. and Shea, L.D. , “Plasmid Releasing Multiple Channel Bridges for Transgene Expression after Spinal Cord Injury,“ Mol Ther 2009, 17(2), 318, PMCID in process.

Rea, J., Gibly, R., Barron, A., Shea , L.D. , “Self-Assembling Peptide-Lipoplexes for Substrate-Mediated Gene Delivery,“ Acta Biomaterialia 2009, 5(3), 903-12. PMCID in process.

Rives, C.D., des Rieux, A., Zelivyanskaya, M., Stock, S.R., Lowe, Jr., W.L., Shea, L.D. , “Layered PLG Scaffolds for In Vivo Plasmid Delivery,” Biomaterials 2009, 30(3), 394-401. PMCID in process.

Stendahl, J.C., Kaufman, D.B. and Stupp, S.I. , “Extracellular Matrix in Pancreatic Islets: Relevance to Scaffold Design and Transplantation,” Cell Transplantation 2009, 18(1), 1-12. NIHMSID: NIHMS124223

Accepted for Publication
Hung, A. M. and Stupp, S.I. , “Understanding Factors Affecting Alignment of Self-Assembling Nanofibers Patterned by Sonication-Assisted Solution Embossing,” Langmuir 2009, In Press.

Des Rieux, A., Shikanov, A. and Shea, L.D. , “Fibrin Hydrogels as Non-viral Vector Delivery Systems for Tissue Engineering,“ J Cont Rel 2009, In press. PMCID in process.

Ray, T., Huang, A., West, E., Zelivyanskaya, M. and Shea, L.D. , “Spatially Patterned Gene Expression for Guided Neurite Extension,” J. Neurosci Res 2009, In press. PMC Journal in process.

Yang, Y., DeLaporte, L., Zelivyanskaya, M., Cummings, B., Anderson , A. and Shea, L.D. , “ Multiple Channel Bridge in the Injured Spinal Cord: Characterization of Host Response,” Tissue Eng . 2009, In press.

Invention Disclosures
NU23091, 10/13/03, Biodegradable, Drug-Releasing Tubes For Tissue Engineering And Regeneration; Lonnie Shea, Kevin J. Whittlesey, Yang Yang, Mark Rovedo, Christopher Rives, Laura De Laporte, Jae-Hyung Jang

NU 23098 , 11/5/03 , Use of Self-Assembling Peptide Amphiphiles to Prevent Tumor Formation by Transplanted Embryonic Stem Cells or to Treat Cancers, John A. Kessler. LiRu Zhao

NU25011, 2/10/05, Heparin-Binding Peptide Amphiphile, Samuel Stupp, Janes Hulvat, Kanya Rajangam

NU25077, 8/15/05, Microporous Polymer Scaffolds for Islet Transplantation; William Lowe, Lonnie Shea, Dixon Kaufman

NU26032, 3/2/06, Heparin-Binding Peptide Amphiphile, Samuel Stupp, James Hulvat, Kanya Rajangam

NU26071, 5/15/06, Self-Assembling Nanofiber Unit For Combined Anti-Sexually Transmitted (STD) / Contraception, Teresa Woodruff, Samuel Stupp, Kasturi Haldar, James Hulvat

NU26073, 5/18/06, Self-Assembling Gel System For Treatment Of Myocardial Infarction And Ischemia, Samuel Stupp, Jon Lomasney, James Hulvat, Xiaoqiang Han, Kanya Rajangam

NU26107, 12/7/07, Compositions and Methods for Magnetic Resonance Imaging Contrast Agents , Serial No. 11/952,691; Annelise Barron, Thomas L. Meade, Lindsay Karfeld (Sulzer), Steve Bull

NU27009, 1/23/07, Self-Assembly at a Liquid-Liquid Interphase: Formation of Membranes, Sacs, and Strings, Ramille Capito, Helena Azevedo, Samuel I. Stupp

NU27055, 4/18/07, Macromonomers and Hydrogel Systems using Native Chemical Ligation; PCT/US08/060994 filed with US patent office, 4/21/2008, Phillip B. Messersmith, Bi-Huang Hu, Jing Su

NU27090, 6/20/07, Extracellular Matrix Protein-Coated Scaffolds Promote The Reversal Of Diabetes Following Extrahepatic Islet Transplantation; William Lowe, Lonnie Shea, David Salvay

NU27116, 8/15/07, DNA-Binding Self-Assembling Peptide Amphiphile System For The Transfection Of Cellular Aggregates, Samuel Stupp, Chung-Yan Koh

NU27154, 10/26/07, (1) Layered Polymer Scaffolds for Protein and DNA Delivery (2) Exendin-4 Releasing Scaffolds for Islet Transplantation; William Lowe, Jr., Lonnie Shea, Christopher Rives, Anne des Rieux