Melina Kibbe

Associate Professor, Department of Surgery Vascular Surgery Division MD (1994) University of Chicago m-kibbe@md.northwestern.edu Area of Interest: Nitric oxide vascular biology
Melina Kibbe focuses her research on nitric oxide vascular biology.  Specifically, she is studying how nitric oxide inhibits vascular smooth muscle cell proliferation by focusing on the role of nitric oxide in regulating the cell cycle and the ubiquitin-proteasome pathway. She also explores how nitric oxide induces vascular smooth muscle cell apoptosis through p53 and reactive oxygen species.  She is developing and testing nitric oxide-based pharmacological approaches to inhibit neointimal hyperplasia following vascular bypass grafting.  This technology ranges from nitric oxide-eluting gels, biofilms, and prosthetic vascular grafts.  Her hope is to have a positive effect on patency rates of open and endovascular surgical procedures, thereby effecting millions of patients that undergo coronary artery or peripheral artery bypass procedures.
Kibbe Research Group

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