Seminars and Special Events
IBNAM/Chemistry Special Seminar: Re-patterning the T cell immunological synapse with nanopatterned supported membranes
Jay T. Groves
Department of Chemistry
UC Berkeley
Berkeley CA 94720
Friday, November 18, 2005
4pm*
Tech LR3**
Surfaces create an environment in which multiple forces conspire
together to yield a wealth of complex chemical processes. This is
especially true of cell membrane surfaces, whose fluidity and
flexibility enables responsive feedback with surface chemical
interactions in ways not generally seen with inorganic materials. As a
prominent example, spatial pattern formation of cell surface proteins
is emerging as a functional aspect of intercellular signaling. In this
lecture, I will discuss experimental strategies to probe and manipulate
the cell surface based on hybrid junctions between living cells and
nanofabricated solid substrates. This configuration allows imposition
of spatial constraints on the motion of proteins in living T cells from
structures fabricated onto the substrate. Experiments reveal a
mechanism by switch spatial patterning may regulate immune cell
signaling. In more chemical language, I will discuss how geometrical
constraints can modulate the chemical outcome of a reaction.
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*Coffee and cookies will be served at 3:30pm
**Technological Institute, Room LR3, 2145 Sheridan Rd, Evanston
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